The IYRC
  • Home
  • 2023 Conference
    • Submission & Presentation Guidelines
    • Paper Submission
    • FAQ
  • 2023 Summer Program
    • About
    • Application
    • Pre-orientation Program
  • Past Conferences
    • IYRC Fall 2022
    • IYRC Fall 2021 >
      • Authors
      • IYRC Fall 2021 Proceedings
      • Schedule
      • Keynote Speakers
    • IYRC Spring 2021 >
      • Authors
      • Scholarship
      • Schedule
      • Keynote Speakers
    • IYRC 2020 >
      • IYRC 2020 Proceedings
      • Guest Speakers
      • Events >
        • HCJI Panel
        • Guest Speaker - Molly Edwards
        • Guest Speaker - Paul Lewis
    • IYRC 2019 Proceedings
    • IYRC 2018 Proceedings
  • Past Summer Programs
    • IYRC Summer 2022
    • IYRC Summer 2021
  • About
    • Programs
    • Partnerships
    • Who we are
    • Gallery
    • Testimonials
  • Contact Us

Development of an Aptamer-Gold Nanoparticle Assay for Field Use in Informing “DIY- HRT”

by Arthur Liang
Category: STEM
Abstract – Most individuals on Feminizing Hormone Therapy receive their medications from a conventional supply chain. However, some utilize non-medical sources because they do not have access to medical care, have difficulty covering the cost, or distrust the medical establishment. Using a non-licensed supplier heightens the uncertainty that the hormone procured is the hormone received. Here, we aim to develop highly affinitive and selective aptamers for progesterone and testosterone for field-ready hormone detection “drug tests”. A good aptamer is characterized by high sensitivity and specificity for a specific target so discrimination against interfering agents is important for minimizing false positives. Researchers have identified several promising features and motifs of nucleotide sequences, stems, loops, and three-way junctions that may amplify aptamer specificity for targets. As a part of our testing procedure, we analyzed several existing progesterone and testosterone aptamers and developed our own using the MFold Web Server. We then characterized their performance in a visible to the eye colorimetric gold-nanoparticle (AuNP) assay to identify several promising testosterone and progesterone aptamers for further testing.
  • PAPER
  • PRESENTATION VIDEO
<
>
Download PDF
Contact us: ​info@the-iyrc.org
  • Home
  • 2023 Conference
    • Submission & Presentation Guidelines
    • Paper Submission
    • FAQ
  • 2023 Summer Program
    • About
    • Application
    • Pre-orientation Program
  • Past Conferences
    • IYRC Fall 2022
    • IYRC Fall 2021 >
      • Authors
      • IYRC Fall 2021 Proceedings
      • Schedule
      • Keynote Speakers
    • IYRC Spring 2021 >
      • Authors
      • Scholarship
      • Schedule
      • Keynote Speakers
    • IYRC 2020 >
      • IYRC 2020 Proceedings
      • Guest Speakers
      • Events >
        • HCJI Panel
        • Guest Speaker - Molly Edwards
        • Guest Speaker - Paul Lewis
    • IYRC 2019 Proceedings
    • IYRC 2018 Proceedings
  • Past Summer Programs
    • IYRC Summer 2022
    • IYRC Summer 2021
  • About
    • Programs
    • Partnerships
    • Who we are
    • Gallery
    • Testimonials
  • Contact Us