Evaluating candidate IRAP inhibitors in Ginkgo biloba extract and their potential for cognitive enhancement
by Napoleon Star
Abstract – Ginkgo biloba is commonly used as an alternative medicine and is known for its nootropic effects. It contains many secondary metabolites, including terpene lactones and flavone glycosides. However, the molecular mechanisms of its cognitive enhancement are not well understood. Inhibition of Insulin regulated aminopeptidase (IRAP) has been shown to improve memory in previous studies. Here, we aim to compare the binding affinities of bioactive molecules in Ginkgo biloba extract to known IRAP inhibitors. Using an in silico approach, we found that Ginkgolide B had a similar result to AngIV, yet what surprised us was the difference between the structures. Furthermore, Luteolin and HFI-142 almost identical predicted binding affinities and full fitness values. These findings provide new insight into the possible molecular underpinnings of Ginkgo biloba’s memory-enhancing effects.